Identification of Optimal Mouse Models of Systemic Sclerosis by Interspecies Comparative Genomics
Abstract
Understanding the pathogenesis of systemic sclerosis (SSc) is confounded by considerable disease heterogeneity. Animal models of SSc that recapitulate distinct subsets of disease at the molecular level have not been delineated. We applied interspecies comparative analysis of genomic data from multiple mouse models of SSc and patients with SSc to determine which animal models best reflect the SSc intrinsic molecular subsets.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 27, 2016
- Source ID
- 10.1002/art.39658
Entities
People
- Adam Harris
- Antonios O. Aliprantis
- Carol M. Artlett
- Chelsea Burgwin
- Elizabeth P. Blankenhorn
- Jaclyn Taroni
- Jennifer L. Sargent
- John Varga
- Jun Wei
- Kristen B. Long
- Matthew B Greenblatt
- Michael L. Whitfield
- Mingâhua Wu
- Raphael Lemaire
- Robert Lafyatis
- Stephen H. Clark
- Zhenghui Li
Organizations
- Boston University
- Brigham and Women's Hospital
- Drexel University
- Geisel School of Medicine
- National Institutes of Health
- Northwestern University
- Scleroderma Research Foundation
- United States Department of Defense
- University of Connecticut