Role of ADAMTS‐12 in Protecting Against Inflammatory Arthritis in Mice By Interacting With and Inactivating Proinflammatory Connective Tissue Growth Factor
Abstract
It has been reported that ADAMTS‐12 is a susceptibility gene for rheumatoid arthritis (RA) development, and its level is significantly increased in RA patients. In addition, ADAMTS‐12 is reported to be required for inflammation in otherwise healthy subjects. This study was undertaken to determine the role of ADAMTS‐12 and the underlying mechanisms in the pathogenesis of inflammatory arthritis.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 24, 2018
- Source ID
- 10.1002/art.40552
Entities
People
- Aubryanna Hettinghouse
- Chuan‐ju Liu
- Jian‐lu Wei
- Kenneth E. Lipson
- Wenyu Fu
- Wen‐jun He
Organizations
- NYU Langone Health
- National Institutes of Health
- New York University
- United States Department of Defense