Triple Positivity for Anti–Citrullinated Protein Autoantibodies, Rheumatoid Factor, and Anti–Carbamylated Protein Antibodies Conferring High Specificity for Rheumatoid Arthritis
Abstract
In rheumatoid arthritis (RA), anti–citrullinated protein antibodies (ACPAs) and rheumatoid factor (RF) are commonly used to aid in the diagnosis. Although these autoantibodies are mainly found in RA, their specificity is not optimal. It is therefore difficult to identify RA patients, especially in very early disease, based on the presence of ACPAs and RF alone. In addition, anti–carbamylated protein (anti‐CarP) antibodies have diagnostic and prognostic value, since their presence is associated with joint damage in RA patients and also associated with the future development of RA in patients with arthralgia. Therefore, the aim of the present study was to investigate the value of combined antibody testing in relation to prediction and diagnosis of (early) RA.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 16, 2018
- Source ID
- 10.1002/art.40562
Entities
People
- Annette H. M. Van Der Helm‐van Mil
- Diane Van Der Woude
- Jess D. Edison
- Johanna Westra
- Jonathan D. Jones
- Kevin D Deane
- Koen M. J. Janssen
- Leendert A. Trouw
- Marije K. Verheul
- Mikael Brink
- Myrthe A. M. Van Delft
- Rene E. M. Toes
- Ryan W. Gan
- Solbritt Rantapää‐dahlqvist
- Stefan Böhringer
- Tom W. J. Huizinga
- V. Michael Holers
- William F. C. Rigby
Organizations
- Colorado School of Public Health
- Geisel School of Medicine
- Leiden University
- Umeå University
- United States Department of Defense
- University of Colorado Boulder
- University of Groningen
- Walter Reed National Military Medical Center