Disordered Antigens and Epitope Overlap Between Anti–Citrullinated Protein Antibodies and Rheumatoid Factor in Rheumatoid Arthritis
Abstract
Anti–citrullinated protein antibodies (ACPAs) and rheumatoid factor (RF) are commonly present in rheumatoid arthritis (RA) without a clear rationale for their coexistence. Moreover, autoantibodies develop against proteins with different posttranslational modifications and native proteins without obvious unifying characteristics of the antigens. We undertook this study to broadly evaluate autoantibody binding in seronegative and seropositive RA to identify novel features of reactivity.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Dec 10, 2019
- Source ID
- 10.1002/art.41074
Entities
People
- Aisha M. Mergaert
- Alan J. Bridges
- Caitlyn L. Holmes
- Irene M. Ong
- Lauren M. Fahmy
- Mandar Bawadekar
- Michael A. Newton
- Miriam A. Shelef
- Zihao Zheng
Organizations
- Congressionally Directed Medical Research Programs
- Doris Duke Charitable Foundation
- National Cancer Institute
- National Heart, Lung, and Blood Institute
- National Institute of Allergy and Infectious Diseases
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- University of Wisconsin–Madison