Muscle Weakness in Myositis: MicroRNA‐Mediated Dystrophin Reduction in a Myositis Mouse Model and Human Muscle Biopsies
Abstract
Muscle inflammation is a feature in myositis and Duchenne muscular dystrophy (DMD). Autoimmune mechanisms are thought to contribute to muscle weakness in patients with myositis. However, a lack of correlation between the extent of inflammatory cell infiltration and muscle weakness indicates that nonimmune pathologic mechanisms may play a role. The present study focused on 2 microRNA (miRNA) sets previously identified as being elevated in the muscle of patients with DMD—an “inflammatory” miRNA set that is dampened with glucocorticoids, and a “dystrophin‐targeting” miRNA set that inhibits dystrophin translation—to test the hypothesis that these miRNAs are similarly dysregulated in the muscle of patients with myositis, and could contribute to muscle weakness and disease severity.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 31, 2020
- Source ID
- 10.1002/art.41215
Entities
People
- Alyson A Fiorillo
- Christopher B. Tully
- Christopher Heier
- Eric Hoffman
- Jack H. Van der Muelen
- Kanneboyina Nagaraju
- Travis B. Kinder
Organizations
- Binghamton University
- Children's National Hospital
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- Foundation To Eradicate Duchenne
- George Washington University
- National Heart, Lung, and Blood Institute
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- United States Department of Defense