Aberrant Salience? Brain Hyperactivation in Response to Pain Onset and Offset in Fibromyalgia
Abstract
While much brain research on fibromyalgia (FM) focuses on the study of hyperresponsiveness to painful stimuli, some studies suggest that the increased pain‐related brain activity often reported in FM studies may be partially explained by stronger responses to salient aspects of the stimulation rather than, or in addition to, the stimulation's painfulness. Therefore, this study was undertaken to test our hypothesis that FM patients would demonstrate elevated brain responses to both pain onset and offset—2 salient sensory events of opposing valences.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 21, 2020
- Source ID
- 10.1002/art.41220
Entities
People
- Asimina Lazaridou
- Catherine S. Hubbard
- Christine M. Cahalan
- Jieun Kim
- Marco L Loggia
- Robert R. Edwards
- Vitaly Napadow
Organizations
- Brigham and Women's Hospital
- Harvard Medical School
- International Association for the Study of Pain
- Massachusetts General Hospital
- National Center for Complementary and Integrative Health
- National Center for Research Resources
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- National Institute of Neurological Disorders and Stroke
- United States Department of Defense