Profibrotic Activation of Human Macrophages in Systemic Sclerosis

Abstract

Genome‐wide gene expression studies implicate macrophages as mediators of fibrosis in systemic sclerosis (SSc), but little is known about how these cells contribute to fibrotic activation in SSc. We undertook this study to characterize the activation profile of SSc monocyte‐derived macrophages and assessed their interaction with SSc fibroblasts.

Document Details

Document Type
Pub Defense Publication
Publication Date
May 31, 2020
Source ID
10.1002/art.41243

Entities

People

  • Dillon Popovich
  • Esperanza Arroyo
  • Evelien Schaafsma
  • Kathleen Aren
  • Mary Carns
  • Michael Ball
  • Michael Whitfield
  • Mohamed A ElTanbouly
  • Monique Hinchcliff
  • Nicole Orzechowski
  • Patricia A Pioli
  • Rajan Bhandari
  • Saemi Han
  • Viktor Martyanov

Organizations

  • Congressionally Directed Medical Research Programs
  • Dartmouth–Hitchcock Medical Center
  • Dr. Ralph and Marian Falk Medical Research Trust
  • Geisel School of Medicine
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases
  • Northwestern University
  • Scleroderma Foundation
  • Scleroderma Research Foundation

Tags

Fields of Study

  • Medicine

Readers

  • Immunology and Pathology