Modulation of Hedgehog Signaling by Kappa Opioids to Attenuate Osteoarthritis

Abstract

Inhibition of hedgehog (HH) signaling prevents cartilage degeneration and promotes repair in animal models of osteoarthritis (OA). This study, undertaken in OA models and in human OA articular cartilage, was designed to explore whether kappa opioid receptor (KOR) modulation via the inhibition of HH signaling may have therapeutic potential for achieving disease‐modifying activity in OA.

Document Details

Document Type
Pub Defense Publication
Publication Date
Jun 24, 2020
Source ID
10.1002/art.41250

Entities

People

  • Alexander E. Weber
  • Denis Evseenko
  • Erik N. Mayer
  • Frank A. Petrigliano
  • Jay R. Lieberman
  • Liangliang Li
  • Liming Wang
  • Nancy Q. Liu
  • Omid Jalali
  • Robert Van Der Horst
  • Ruzanna Shkhyan
  • Sean Limfat
  • Siyoung Lee
  • Yucheng Lin

Organizations

  • Nanjing Medical University
  • National Institutes of Health
  • United States Department of Defense
  • University of Southern California

Tags

Fields of Study

  • Biology
  • Medicine

Readers

  • Molecular Biology and Genetics
  • Neurotrauma and Rehabilitation Medicine.