Attenuation of Murine Collagen‐Induced Arthritis by Targeting CD6
Abstract
CD6 is an important regulator of T cell function that interacts with the ligands CD166 and CD318. To further clarify the significance of CD6 in rheumatoid arthritis (RA), we examined the effects of targeting CD6 in the mouse model of collagen‐induced arthritis (CIA), using CD6‐knockout (CD6‐KO) mice and CD6‐humanized mice that express human CD6 in lieu of mouse CD6 on their T cells.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 14, 2020
- Source ID
- 10.1002/art.41288
Entities
People
- Daniel P. Weber
- David A. Fox
- Feng Lin
- Jeffrey H. Ruth
- Kalana S. Athukorala
- M. Asif Amin
- Nora G. Singer
- Phillip L. Campbell
- Stephanie M. Rasmussen
- Yan Li
Organizations
- Cleveland Clinic
- MetroHealth
- National Institutes of Health
- United States Department of Defense
- University of Michigan