Mechanosensitive Control of Articular Cartilage and Subchondral Bone Homeostasis in Mice Requires Osteocytic Transforming Growth Factor β Signaling

Abstract

Transforming growth factor β (TGFβ) signaling plays a complex tissue‐specific and nonlinear role in osteoarthritis (OA). This study was conducted to determine the osteocytic contributions of TGFβ signaling to OA.

Document Details

Document Type
Pub Defense Publication
Publication Date
Feb 01, 2021
Source ID
10.1002/art.41548

Entities

People

  • Alexis Dang
  • Cristal S. Yee
  • Jeffrey Nguyen
  • Karsyn N Bailey
  • Neha S Dole
  • Tamara Alliston

Organizations

  • National Institute of Dental and Craniofacial Research
  • National Institute of General Medical Sciences
  • National Science Foundation
  • United States Department of Defense
  • University of California, San Francisco

Tags

Fields of Study

  • Chemistry
  • Medicine

Readers

  • Immunology and Pathology
  • Neurotrauma and Rehabilitation Medicine.