Identification of Distinct Inflammatory Programs and Biomarkers in Systemic Juvenile Idiopathic Arthritis and Related Lung Disease by Serum Proteome Analysis
Abstract
Recent observations in systemic juvenile idiopathic arthritis (JIA) suggest an increasing incidence of high‐mortality interstitial lung disease often characterized by a variant of pulmonary alveolar proteinosis (PAP). Co‐occurrence of macrophage activation syndrome (MAS) and PAP in systemic JIA suggests a shared pathology, but patients with lung disease associated with systemic JIA (designated SJIA‐LD) also commonly experience features of drug reaction such as atypical rashes and eosinophilia. This study was undertaken to investigate immunopathology and identify biomarkers in systemic JIA, MAS, and SJIA‐LD.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 31, 2022
- Source ID
- 10.1002/art.42099
Entities
People
- Adriana Almeida De Jesus
- Alexei Grom
- Bruce C Trapnell
- Claudia Macaubas
- Corinne Schneider
- Elizabeth D Mellins
- Gail H Deutsch
- Grant Schulert
- Guangbo Chen
- Hong Zheng
- Katherine Ho
- Mark A Krasnow
- Pui Y Lee
- Purvesh Khatri
- Raphaela T. Goldbach-Mansky
- Scott W Canna
- Sori Jang
- Vivian E. Saper
Organizations
- Boston Children's Hospital
- Gates Foundation
- National Institute of Allergy and Infectious Diseases
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- National Institutes of Health
- Stanford University
- United States Department of Defense
- University of Cincinnati
- University of Pittsburgh Medical Center
- University of Washington