Rational Design of [13C,D14]Tert‐butylbenzene as a Scaffold Structure for Designing Long‐lived Hyperpolarized 13C Probes
Abstract
Dynamic nuclear polarization (DNP) is a technique to polarize the nuclear spin population. As a result of the hyperpolarization, the NMR sensitivity of the nuclei in molecules can be dramatically enhanced. Recent application of the hyperpolarization technique has led to advances in biochemical and molecular studies. A major problem is the short lifetime of the polarized nuclear spin state. Generally, in solution, the polarized nuclear spin state decays to a thermal spin equilibrium, resulting in loss of the enhanced NMR signal. This decay is correlated directly with the spin‐lattice relaxation time T1. Here we report [13C,D14]tert‐butylbenzene as a new scaffold structure for designing hyperpolarized 13C probes. Thanks to the minimized spin‐lattice relaxation (T1) pathways, its water‐soluble derivative showed a remarkably long 13C T1 value and long retention of the hyperpolarized spin state.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 16, 2018
- Source ID
- 10.1002/asia.201701652
Entities
People
- Alexander M. Funk
- Chalermchai Khemtong
- Hiroshi Nonaka
- Kazuhiro Ichikawa
- Nesmine R. Maptue
- Shinsuke Sando
- Yoichi Takakusagi
- Yuki Imakura
Organizations
- Kyushu University
- National Institutes of Health
- United States Department of Defense
- University of Texas at Austin
- University of Tokyo