Hyperpolarized NMR Spectroscopy: d‐DNP, PHIP, and SABRE Techniques
Abstract
The intensity of NMR signals can be enhanced by several orders of magnitude by using various techniques for the hyperpolarization of different molecules. Such approaches can overcome the main sensitivity challenges facing modern NMR/magnetic resonance imaging (MRI) techniques, whilst hyperpolarized fluids can also be used in a variety of applications in material science and biomedicine. This Focus Review considers the fundamentals of the preparation of hyperpolarized liquids and gases by using dissolution dynamic nuclear polarization (d‐DNP) and parahydrogen‐based techniques, such as signal amplification by reversible exchange (SABRE) and parahydrogen‐induced polarization (PHIP), in both heterogeneous and homogeneous processes. The various new aspects in the formation and utilization of hyperpolarized fluids, along with the possibility of observing NMR signal enhancement, are described.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 16, 2018
- Source ID
- 10.1002/asia.201800551
Entities
People
- Basile Vuichoud
- Boyd M Goodson
- Danila A. Barskiy
- Dennis Kurzbach
- Eduard Y. Chekmenev
- Ekaterina V. Pokochueva
- Igor Koptyug
- Kirill V. Kovtunov
- Oleg Salnikov
- Sami Jannin
- Samuel F. Cousin
Organizations
- Congressionally Directed Medical Research Programs
- European Research Council
- Laboratoire des biomolécules
- National Center for Scientific Research
- National Institutes of Health
- National Science Foundation
- Novosibirsk State University
- Russian Academy of Sciences
- Russian Center for Science Information
- Russian Science Foundation
- Southern Illinois University
- United States Department of Defense
- University of California, Berkeley
- University of Lyon
- Wayne State University