Cranial neural crest cell contribution to craniofacial formation, pathology, and future directions in tissue engineering
Abstract
This review provides an overview of the state and future directions of development and pathology in the craniofacial complex in the context of Cranial Neural Crest Cells (CNCC). CNCC are a multipotent cell population that is largely responsible for forming the vertebrate head. We focus on findings that have increased the knowledge of gene regulatory networks and molecular mechanisms governing CNCC migration and the participation of these cells in tissue formation. Pathology due to aberrant migration or cell death of CNCC, termed neurocristopathies, is discussed in addition to craniosynostoses. Finally, we discuss tissue engineering applications that take advantage of recent advancements in genome editing and the multipotent nature of CNCC. These applications have relevance to treating diseases due directly to the failure of CNCC, and also in restoring tissues lost due to a variety of reasons. Birth Defects Research (Part C) 102:324–332, 2014. © 2014 Wiley Periodicals, Inc.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 01, 2014
- Source ID
- 10.1002/bdrc.21075
Entities
People
- Taylor Nicholas Snider
- Yuji Mishina
Organizations
- National Institute of Dental and Craniofacial Research
- United States Department of Defense
- University of Michigan