Rapid self‐assembly of γPNA nanofibers at constant temperature
Abstract
Peptide nucleic acids (PNAs) have primarily been used to achieve therapeutic gene modulation through antisense strategies since their design in the 1990s. However, the application of PNAs as a functional nanomaterial has been more recent. We recently reported that γ‐modified peptide nucleic acids (γPNAs) could be used to enable formation of complex, self‐assembling nanofibers in select polar aprotic organic solvent mixtures. Here we demonstrate that distinct γPNA strands, each with a high density of γ‐modifications can form complex nanostructures at constant temperatures within 30 minutes. Additionally, we demonstrate DNA‐assisted isothermal growth of γPNA nanofibers, thereby overcoming a key hurdle for future scale‐up of applications related to nanofiber growth and micropatterning.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 02, 2021
- Source ID
- 10.1002/bip.23463
Entities
People
- Danith H. Ly
- Isha Dhami
- Rebecca E Taylor
- Shivaji A. Thadke
- Sriram Kumar
Organizations
- Air Force Office of Scientific Research
- Carnegie Mellon University
- DSF Charitable Foundation
- National Science Foundation