Structure‐guided identification of a peptide for bio‐enabled gold nanoparticle synthesis
Abstract
In this study, we show that maltose‐binding protein (MBP) is capable of facilitating stable gold nanoparticle synthesis, and a structure of MBP in the presence of gold ions was determined by X‐ray crystallography. Using this high‐resolution structure of gold ion bound MBP, a peptide (AT1) was selected and synthesized and was shown to also aid in the synthesis of stable gold nanoparticles under similar experimental conditions to those used for protein facilitated synthesis. This structure‐based approach represents a new potential method for the selection of peptides capable of facilitating stable nanoparticle synthesis.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 06, 2021
- Source ID
- 10.1002/bit.27927
Entities
People
- Amar Thaker
- Brent Nannenga
- Chad R Simmons
- Luqmanal Sirajudeen
Organizations
- Air Force Office of Scientific Research
- Arizona State University