Bisphosphonate–ciprofloxacin bound to Skelite™ is a prototype for enhancing experimental local antibiotic delivery to injured bone
Abstract
The risk of osteomyelitis after open bone fracture may be reduced by locally applied antibiotics. ENC-41-HP (E41), which comprises ciprofloxacin linked to a ‘bone seeking’ bisphosphonate, loaded on to carrier Skelite™ calcium phosphate granules (E41-Skelite™) has favourable in vitro characteristics for application to wounded bone. This study assessed E41-Skelite™ in a rat model of acute tibial osteomyelitis.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 06, 2004
- Source ID
- 10.1002/bjs.4644
Entities
People
- D S Walsh
- J C Mcpherson Iii
- J F Hartmann
- K. M. Plowman
- S B Harvey
- T B Buxton
Organizations
- Dwight D. Eisenhower Army Medical Center