Remodeling of brain morphology in temporal lobe epilepsy
Abstract
Mesial temporal lobe epilepsy (TLE) is one of the most widespread neurological network disorders. Computational anatomy MRI studies demonstrate a robust pattern of cortical volume loss. Most statistical analyses provide information about localization of significant focal differences in a segregationist way. Multivariate Bayesian modeling provides a framework allowing inferences about inter‐regional dependencies. We adopt this approach to answer following questions: Which structures within a pattern of dynamic epilepsy‐associated brain anatomy reorganization best predict TLE pathology. Do these structures differ between TLE subtypes?
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 17, 2020
- Source ID
- 10.1002/brb3.1825
Entities
People
- Bogdan Draganski
- Elisabeth Roggenhofer
- Emiliano Santarnecchi
- Ferath Kherif
- Lester Melie-García
- Roland Wiest
- Sandrine Muller
Organizations
- ETH Zurich
- Fondation Leenaards
- Geneva University Hospitals
- Harvard Medical School
- Intelligence Advanced Research Projects Activity
- Max Planck Society
- University of Bern
- University of Lausanne
- University of Siena