Phenotypic characterization of frontal cortex microglia in a rat model of post‐traumatic stress disorder
Abstract
Post‐traumatic stress disorder (PTSD) is an anxiety disorder induced by psychologically traumatic events. Using a rat model, this study aimed to determine whether psychological trauma alters relative expression between pro‐inflammatory and anti‐inflammatory markers in microglia. To meet this goal, expression of genes encoding i‐NOS, arginase, TNF‐α, interleukin‐10, CD74, and Mannose Receptor C was analyzed on multiple days following trauma exposure.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 12, 2021
- Source ID
- 10.1002/brb3.2011
Entities
People
- Angus G. Scrimgeour
- Charina B. Hocog
- Heather M. Sullivan
- Joseph T. Ramsey
- Marcus A. Sanchez
- Thomas S. Cotrone
Organizations
- United States Army Research Institute of Environmental Medicine
- United States Department of Defense