Linking kindling to increased glutamate release in the dentate gyrus of the hippocampus through the STXBP5/tomosyn‐1 gene
Abstract
In kindling, repeated electrical stimulation of certain brain areas causes progressive and permanent intensification of epileptiform activity resulting in generalized seizures. We focused on the role(s) of glutamate and a negative regulator of glutamate release, STXBP5/tomosyn‐1, in kindling.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 13, 2017
- Source ID
- 10.1002/brb3.795
Entities
People
- Elena A. Matveeva
- Greg A. Gerhardt
- John T. Slevin
- Seth R Batten
- Sidney Whiteheart
- Thomas C. Vanaman
Organizations
- Defense Advanced Research Projects Agency
- National Institutes of Health
- United States Department of Veterans Affairs
- University of Kentucky
- Veterans Health Administration