Impact of treatment on progression to castration‐resistance, metastases, and death in men with localized high‐grade prostate cancer
Abstract
Men with high‐grade prostate cancer (HGPC) are at greatest risk of disease progression. Clinical risk factors associated with castration‐resistant prostate cancer (CRPC), metastases, and prostate cancer‐specific mortality (PCSM) were identified in a contemporary HGPC cohort. Clinical data was collected from men diagnosed with Gleason sum (GS) ≥8 at the Greater Los Angeles Veterans Affairs (GLA‐VA) Healthcare System between 2000 and 2013. Multivariable competing risks regression analyses assessed progression to CRPC, metastases, and PCSM within three treatment strata. The cumulative incidence of disease progression was calculated at 2, 5, and 10‐year time points. Review of 2149 prostate cancer cases yielded 322 with HGPC. Median survival times for cancer‐specific and overall mortality were significantly shorter in men treated with primary androgen deprivation therapy (ADT) (P = 0.0002 and P GS 10, and treatment with primary ADT were significantly associated with increased risk of CRPC, metastases, and PCSM. Significant differences in these outcomes were not observed in men treated with radical prostatectomy (RP) when compared to those treated with radiation therapy combined with short‐term ADT (XRT‐ADT). Ten‐year event rates of progression to CRPC, metastases, and PCSM, for men treated with primary ADT, were 45.5%, 25.4%, and 25.1%, respectively. In conclusion, GS 10 and lymph node involvement, as well as primary ADT treatment in men with HGPC was associated with increased risk of CRPC, metastases, and PCSM. Curative‐intent treatment with RP or XRT‐ADT is associated with reduced progression rates and death in men with HGPC.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Dec 20, 2016
- Source ID
- 10.1002/cam4.981
Entities
People
- Beatrice S Knudsen
- Eric T. Miller
- Isla P Garraway
- Karim Chamie
- Lorna Kwan
- Michael Lewis
Organizations
- Cedars-Sinai Medical Center
- Jean Perkins Foundation
- Movember Foundation
- National Institutes of Health
- Prostate Cancer Foundation
- Stop Cancer
- UCLA David Geffen School of Medicine
- United States Department of Defense
- University of California, Los Angeles