Regulating DNA Self‐assembly by DNA–Surface Interactions
Abstract
DNA self‐assembly provides a powerful approach for preparation of nanostructures. It is often studied in bulk solution and involves only DNA–DNA interactions. When confined to surfaces, DNA–surface interactions become an additional, important factor to DNA self‐assembly. However, the way in which DNA–surface interactions influence DNA self‐assembly is not well studied. In this study, we showed that weak DNA–DNA interactions could be stabilized by DNA–surface interactions to allow large DNA nanostructures to form. In addition, the assembly can be conducted isothermally at room temperature in as little as 5 seconds.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 09, 2017
- Source ID
- 10.1002/cbic.201700545
Entities
People
- Chengde Mao
- Jianwei Zheng
- Longfei Liu
- Yong Wang
- Yulin Li
Organizations
- Capital Medical University
- Hefei University of Technology
- Nanchang University
- National Science Foundation
- Office of Naval Research
- Purdue University