Towards Non‐stick Silk: Tuning the Hydrophobicity of Silk Fibroin Protein
Abstract
Silk fibroin protein is a biomaterial with excellent biocompatibility and low immunogenicity. These properties have catapulted the material as a leader for extensive use in stents, catheters, and wound dressings. Modulation of hydrophobicity of silk fibroin protein to further expand the scope and utility however has been elusive. We report that installing perfluorocarbon chains on the surface of silk fibroin transforms this water‐soluble protein into a remarkably hydrophobic polymer that can be solvent‐cast. A clear relationship emerged between fluorine content of the modified silk and film hydrophobicity. Water contact angles of the most decorated silk fibroin protein exceeded that of Teflon®. We further show that water uptake in prefabricated silk bars is dramatically reduced, extending their lifetimes, and maintaining mechanical integrity. These results highlight the power of chemistry under moderate conditions to install unnatural groups onto the silk fibroin surface and will enable further exploration into applications of this versatile biomaterial.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 22, 2022
- Source ID
- 10.1002/cbic.202200429
Entities
People
- David L. Kaplan
- Jugal Kishore Sahoo
- Julia N. Fountain
- Junqi Wu
- Krishna Kumar
- Lauren Hartle
- Luke M Davis
- Morgan J Hawker
- Vittorio Montanari
Organizations
- Air Force Office of Scientific Research
- California State University, Fresno
- National Institutes of Health
- National Science Foundation
- Tufts University