Advanced Continuous Flow Platform for On‐Demand Pharmaceutical Manufacturing
Abstract
As a demonstration of an alternative to the challenges faced with batch pharmaceutical manufacturing including the large production footprint and lengthy time‐scale, we previously reported a refrigerator‐sized continuous flow system for the on‐demand production of essential medicines. Building on this technology, herein we report a second‐generation, reconfigurable and 25 % smaller (by volume) continuous flow pharmaceutical manufacturing platform featuring advances in reaction and purification equipment. Consisting of two compact [0.7 (L)×0.5 (D)×1.3 m (H)] stand‐alone units for synthesis and purification/formulation processes, the capabilities of this automated system are demonstrated with the synthesis of nicardipine hydrochloride and the production of concentrated liquid doses of ciprofloxacin hydrochloride, neostigmine methylsulfate and rufinamide that meet US Pharmacopeia standards.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 31, 2018
- Source ID
- 10.1002/chem.201706004
Entities
People
- Allan S Myerson
- Andrea Adamo
- Chunhui Dai
- Dale A. Thomas
- Hongkun Lin
- Klavs F. Jensen
- Kohei Tahara
- Liam P. Kelly
- Marcus O'mahony
- Mary Grace Russell
- N.E.B. Briggs
- Nopphon Weeranoppanant
- Ping Zhang
- Rachel L. Beingessner
- Timothy F. Jamison
- Torsten Stelzer
- Yuqing Cui
Organizations
- Burapha University
- Defense Advanced Research Projects Agency
- Gifu Pharmaceutical University
- Massachusetts Institute of Technology
- Novartis
- University of Puerto Rico
- Vertex Pharmaceuticals