Fmoc‐Dipeptide/Porphyrin Molar Ratio Dictates Energy Transfer Efficiency in Nanostructures Produced by Biocatalytic Co‐Assembly
Abstract
The controlled self‐assembly of porphyrin derivatives (TCPP, tetrakis(4‐carboxyphenyl)porphyrin) within Fmoc‐protected (Fmoc=9‐Fluorenylmethyloxycarbonyl) dipeptide (Fmoc‐TL‐NH2) nanofibers is demonstrated. The biocatalytic co‐assembly in aqueous medium generated an energy transfer hydrogel. Depending on the concentrations of porphyrin used, the resulting nanofibrous gels show two distinct regions of self‐assembly behavior that is, integration of TCPP into nanostructures to produce two‐component co‐assembly fibers, or heterogeneous self‐aggregation of TCPP within the self‐assembled matrix observed at higher concentrations. The mode of assembly directly impacts on the energy transfer efficiency of these nanostructures. These results show that reversible biocatalytic co‐assembly of structural and functional components enables fine‐tuning of peptide/porphyrin energy transfer nanostructures.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 21, 2019
- Source ID
- 10.1002/chem.201902819
Entities
People
- Mohit Kumar
- Nadeesha K Wijerathne
- Rein V Ulijn
Organizations
- Air Force Office of Scientific Research
- Army Research Office
- CUNY Graduate School and University Center
- City University of New York