Low‐Flammable Parahydrogen‐Polarized MRI Contrast Agents
Abstract
Many MRI contrast agents formed with the parahydrogen‐induced polarization (PHIP) technique exhibit biocompatible profiles. In the context of respiratory imaging with inhalable molecular contrast agents, the development of nonflammable contrast agents would nonetheless be highly beneficial for the biomedical translation of this sensitive, high‐throughput and affordable hyperpolarization technique. To this end, we assess the hydrogenation kinetics, the polarization levels and the lifetimes of PHIP hyperpolarized products (acids, ethers and esters) at various degrees of fluorine substitution. The results highlight important trends as a function of molecular structure that are instrumental for the design of new, safe contrast agents for in vivo imaging applications of the PHIP technique, with an emphasis on the highly volatile group of ethers used as inhalable anesthetics.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 07, 2021
- Source ID
- 10.1002/chem.202004168
Entities
People
- Baptiste Joalland
- Eduard Y. Chekmenev
- Hassan R. Younes
- Igor Koptyug
- Juri Gelovani
- Kirill V. Kovtunov
- Nikita Chukanov
- Nuwandi M Ariyasingha
- Oleg Salnikov
- Shiraz Nantogma
Organizations
- Boreskov Institute of Catalysis
- Congressionally Directed Medical Research Programs
- International Tomography Center
- National Heart, Lung, and Blood Institute
- National Science Foundation Directorate for Mathematical & Physical Sciences
- Novosibirsk State University
- Russian Academy of Sciences
- Russian Center for Science Information
- United Arab Emirates University
- Wayne State University