Photochemical Synthesis of the Bioactive Fragment of Salbutamol and Derivatives in a Self‐Optimizing Flow Chemistry Platform
Abstract
The implementation of self‐optimizing flow reactors has been mostly limited to model reactions or known synthesis routes. In this work, a self‐optimizing flow photochemistry platform is used to develop an original synthesis of the bioactive fragment of Salbutamol and derivatives. The key photochemical steps for the construction of the aryl vicinyl amino alcohol moiety consist of a C−C bond forming reaction followed by an unprecedented, high yielding (>80 %), benzylic oxidative cyclization.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 08, 2022
- Source ID
- 10.1002/chem.202201385
Entities
People
- Anirudh M. K. Nambiar
- Klavs F. Jensen
- Prajwal T. Mahesh
- Romaric Gérardy
- Travis Hart
Organizations
- Belgian American Educational Foundation
- Defense Advanced Research Projects Agency
- Massachusetts Institute of Technology