LIM domain proteins in cell mechanobiology
Abstract
The actin cytoskeleton is important for maintaining mechanical homeostasis in adherent cells, largely through its regulation of adhesion and cortical tension. The LIM (Lin‐11, Isl1, MEC‐3) domain‐containing proteins are involved in a myriad of cellular mechanosensitive pathways. Recent work has discovered that LIM domains bind to mechanically stressed actin filaments, suggesting a novel and widely conserved mechanism of mechanosensing. This review summarizes the current state of knowledge of LIM protein mechanosensitivity.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 01, 2021
- Source ID
- 10.1002/cm.21677
Entities
People
- Caitlin A Anderson
- David R. Kovar
- Jonathan D Winkelman
- Margaret Gardel
Organizations
- Army Research Office
- National Institute of General Medical Sciences
- National Institutes of Health
- National Science Foundation
- University of Chicago