Calcium Coordination Solids for pH‐Triggered Release of Olsalazine
Abstract
Calcium coordination solids were synthesized and evaluated for delivery of olsalazine (H4olz), an anti‐inflammatory compound used for treatment of ulcerative colitis. The materials include one‐dimensional Ca(H2olz)⋅4 H2O chains, two‐dimensional Ca(H2olz)⋅2 H2O sheets, and a three‐dimensional metal‐organic framework Ca(H2olz)⋅2DMF (DMF=N,N‐dimethylformamide). The framework undergoes structural changes in response to solvent, forming a dense Ca(H2olz) phase when exposed to aqueous HCl. The compounds Ca(H2olz)⋅x H2O (x=0, 2, 4) were each pressed into pellets and exposed to simulated gastrointestinal fluids to mimic the passage of a pill from the acidic stomach to the pH‐neutral intestines. All three calcium materials exhibited a delayed release of olsalazine relative to Na2(H2olz), the commercial formulation, illustrating how formulation of a drug within an extended coordination solid can serve to tune its solubility and performance.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 06, 2017
- Source ID
- 10.1002/cmdc.201700540
Entities
People
- Christina M. Legendre
- Dana J Levine
- Jeffrey R. Long
- Julia Oktawiec
- Kristen A Colwell
- Miguel I Gonzalez
- Tomče Runčevski
Organizations
- California Institute of Technology
- Lawrence Berkeley National Laboratory
- National Science Foundation
- Office of Basic Energy Sciences
- United States Department of Defense
- University of California, Berkeley
- Yusuf Hamied Department of Chemistry