Impact of germline BRCA1 mutations and overexpression of p53 on prognosis and response to treatment following breast carcinoma
Abstract
Overexpression of p53 has been associated with poor survival following breast carcinoma. BRCA1 interacts biochemically with p53 and may also contribute to poor outcome when constitutionally mutated. The joint effect of both abnormalities has not been studied. The primary objective of this study was to assess the impact of germline BRCA1 mutations and p53 overexpression on survival after 10 years of follow‐up.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 17, 2003
- Source ID
- 10.1002/cncr.11080
Entities
People
- Ann‐josée Paradis
- Jean‐sébastien Brunet
- Jeffrey M Boyd
- John R. Goffin
- Louis R. Bégin
- Nancy Hamel
- Nora Wong
- Pierre O. Chappuis
- William David Foulkes
Organizations
- Fonds de Recherche du Québec Santé
- National Cancer Institute
- United States Army