A regulated multiscale closed‐loop cardiovascular model, with applications to hemorrhage and hypertension
Abstract
A computational tool is developed for simulating the dynamic response of the human cardiovascular system to various stressors and injuries. The tool couples 0‐dimensional models of the heart, pulmonary vasculature, and peripheral vasculature to 1‐dimensional models of the major systemic arteries. To simulate autonomic response, this multiscale circulatory model is integrated with a feedback model of the baroreflex, allowing control of heart rate, cardiac contractility, and peripheral impedance. The performance of the tool is demonstrated in 2 scenarios: neurogenic hypertension by sustained stimulation of the sympathetic nervous system and an acute 10% hemorrhage from the left femoral artery.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 19, 2018
- Source ID
- 10.1002/cnm.2975
Entities
People
- Cayley Bowles
- Daniel Canuto
- Erik P. Dutson
- Jeff D. Eldredge
- Kwitae Chong
- Peyman Benharash
Organizations
- Department of Surgery
- Office of Naval Research