Sex steroid hormone function in the brain niche: Implications for brain metastatic colonization and progression

Abstract

While sex hormones and their receptors play well‐known roles in progression of primary tumors through direct action on sex steroid hormone‐responsive cancer cells, emerging evidence suggest that hormones also play important roles in metastatic progression by modulating the tumor microenvironment. Estrogens and androgens synthesized in gonads and within the brain influence memory, behavior, and outcomes of brain pathologies. Yet, their impact on brain metastatic colonization and progression is just beginning to be explored.

Document Details

• Document Type: Pub Defense Publication
• Publication Date: Mar 03, 2020
• Source ID: 10.1002/cnr2.1241

Entities

People

• Diana M Cittelly
• María J Contreras-Zárate

Organizations

• METAvivor
• National Cancer Institute
• United States Army Materiel Command
• United States Department of Defense
• University of Colorado Denver

Tags

Fields of Study

• Biology

Readers

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• Prostate Cancer Biology.
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