Cortisol promotes breast‐to‐brain metastasis through the blood‐cerebrospinal fluid barrier
Abstract
Elevated basal cortisol levels are present in women with primary and metastatic breast cancer. Although cortisol's potential role in breast‐to‐brain metastasis has yet to be sufficiently studied, prior evidence indicates that it functions as a double‐edged sword—cortisol induces breast cancer metastasis in vivo, but strengthens the blood‐brain‐barrier (BBB) to protect the brain from microbes and peripheral immune cells.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 26, 2021
- Source ID
- 10.1002/cnr2.1351
Entities
People
- Alex Julian
- Behnaz Saatian
- Diganta Das
- Josh Neman
- Krutika Deshpande
- Mukund Iyer
- Rachel Eisenbarth
- Robert A. Herrera
- Vahan Martirosian
Organizations
- METAvivor
- National Cancer Institute
- Susan G. Komen for the Cure
- United States Department of Defense
- University of Southern California