The Use of Stem Cell Therapy to Reverse Opioid Tolerance
Abstract
Opioid tolerance (OT) and opioid‐induced hyperalgesia (OIH) are major challenges in medicine. Here we report that transplantation of mesenchymal stem cells (MSCs) prevented and reversed OT and OIH in rats and mice. The preventive and therapeutic effects were long‐lasting and consistent across different assessment schemes. Both intrathecal and intravenous transplantations were effective and safe. This emerging therapeutic strategy has thus shown promise to impact clinical practice and improve the efficacy and safety of opioid therapy.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Dec 29, 2017
- Source ID
- 10.1002/cpt.959
Entities
People
- Fei Li
- Jianguo Cheng
- Kathleen Cheng
- Liping Liu
- Zhongbo Chen
Organizations
- Qingdao University
- United States Department of Defense