DROSHA but not DICER is required for human haematopoietic stem cell function
Abstract
DROSHA and DICER have central roles in the biogenesis of microRNAs (miRNAs). However, we previously showed that in the murine system, DROSHA has an alternate function where it directly recognises and cleaves protein‐coding messenger (m)RNAs and this is critical for safeguarding the pluripotency of haematopoietic stem cells (HSCs). Maintenance of murine HSC function is dependent on DROSHA‐mediated cleavage of two mRNAs, Myl9 and Todr1. The goal of this study is to determine whether this pathway is conserved in human HSCs.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 01, 2022
- Source ID
- 10.1002/cti2.1361
Entities
People
- Carina Walpole
- Karen Gu
- Kristen J Radford
- Mark M. Chong
- Oscar L. Haigh
- Shayarana Gooneratne
- Xin Liu
Organizations
- Mater Foundation
- National Health and Medical Research Council
- St. Vincent's Institute of Medical Research
- United States Department of Defense
- University of Melbourne
- University of Queensland