Extracellular vesicle expansion of PMIS‐miR‐210 expression inhibits colorectal tumour growth via apoptosis and an XIST/NME1 regulatory mechanism
Abstract
Colorectal cancer (CRC) has a high mortality rate, and therapeutic approaches to treat these cancers are varied and depend on the metabolic state of the tumour. Profiles of CRC tumours have identified several biomarkers, including microRNAs. microRNA‐210 (miR‐210) levels are directly correlated with CRC survival. miR‐210 expression is higher in metastatic colon cancer cells versus non‐metastatic and normal colon epithelium. Therefore, efficient methods to inhibit miR‐210 expression in CRC may provide new advances in treatments.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 01, 2022
- Source ID
- 10.1002/ctm2.1037
Entities
People
- Brad A Amendt
- Camille Chalkley
- Fenghuang Zhan
- Hank H Qi
- Hongwei Xu
- Huojun Cao
- Liu Hong
- Qi Liu
- Steven Eliason
- Yan Sweat
Organizations
- National Cancer Institute
- United States Department of Defense
- University of Iowa