Differences in the intrinsic chondrogenic potential of human mesenchymal stromal cells and iPSC‐derived multipotent cells
Abstract
Human multipotent progenitor cells (hiMPCs) created from induced pluripotent stem cells (iPSCs) represent a new cell source for cartilage regeneration. In most studies, bone morphogenetic proteins (BMPs) are needed to enhance transforming growth factor‐β (TGFβ)‐induced hiMPC chondrogenesis. In contrast, TGFβ alone is sufficient to result in robust chondrogenesis of human primary mesenchymal stromal cells (hMSCs). Currently, the mechanism underlying this difference between hiMPCs and hMSCs has not been fully understood.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Dec 01, 2022
- Source ID
- 10.1002/ctm2.1112
Entities
People
- Eileen Li
- Hang Lin
- Kanyakorn Riewruja
- Karen L. Clark
- Madalyn R. Fritch
- Meagan J. Makarcyzk
- Peter G Alexander
- Shiqi Xiang
- Silvia Liu
- Tingjun Hao
- Xiurui Zhang
- Yiqian Zhang
- Zhong Li
- Zixuan Lin
Organizations
- Central South University
- Chulalongkorn University
- United States Department of Defense
- University of Pittsburgh