Large‐scale sequencing studies expand the known genetic architecture of Alzheimer's disease
Abstract
Genes implicated by genome‐wide association studies and family‐based studies of Alzheimer's disease (AD) are largely discordant. We hypothesized that genes identified by sequencing studies like the Alzheimer's Disease Sequencing Project (ADSP) may bridge this gap and highlight shared biological mechanisms.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 01, 2021
- Source ID
- 10.1002/dad2.12255
Entities
People
- Alan E. Renton
- Alison Goate
- Anita L. Destefano
- Brian W. Kunkle
- Diane Xue
- Edoardo A. Marcora
- Elizabeth Blue
- Ellen Wijsman
- Eric Boerwinkle
- Gerard Schellenberg
- Jonathan L. Haines
- Joshua C. Bis
- Lindsay Farrer
- Margaret Pericak‐vance
- Richard Mayeux
- Sudha Seshadri
- The Alzheimer's Disease Sequencing Project
- William S. Bush
Organizations
- Baylor College of Medicine
- Boston University
- Case Western Reserve University
- Columbia University
- Icahn School of Medicine at Mount Sinai
- Leonard M. Miller School of Medicine
- National Heart, Lung, and Blood Institute
- National Human Genome Research Institute
- National Institute of Neurological Disorders and Stroke
- National Institute on Aging
- National Institutes of Health
- University of Miami
- University of Pennsylvania
- University of Texas at Austin
- University of Washington