Examining the role of repeated test exposure over 12 months across ADNI protocols
Abstract
Objective: Changes to study protocols during longitudinal research may alter cognitive testing schedules over time. Unlike in prior Alzheimer's Disease Neuroimaging Initiative (ADNI) protocols, where testing occurred twice annually, participants enrolled in the ADNI‐3 are no longer exposed to cognitive materials at 6 months. This may affect their 12‐month performance relative to earlier ADNI cohorts, and potentially confounds data harmonization attempts between earlier and later ADNI protocols. Method: Using data from participants enrolled across multiple ADNI protocols, this study investigated whether test exposure during 6‐month cognitive evaluation influenced scores on subsequent 12‐month evaluation. Results: No interaction effects were observed between test exposure group and time at 12 months on cognitive performance. No improvements, and limited declines, were seen between baseline and 12‐month follow‐up scores on most measures. Conclusions: The 6‐month testing session had minimal impact on 12‐month performance in ADNI. Collapsing longitudinal data across ADNI protocols in future research appears appropriate.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 01, 2022
- Source ID
- 10.1002/dad2.12289
Entities
People
- Dustin B. Hammers
- For The Alzheimer’s Disease Neuroimaging Initiative*
- Kevin Duff
- Liana G. Apostolova
Organizations
- Indiana University
- National Institute of Biomedical Imaging and Bioengineering
- National Institute on Aging
- National Institutes of Health
- United States Department of Defense
- University of Utah