Integrative analysis of DNA methylation and gene expression identifies genes associated with biological aging in Alzheimer's disease

Abstract

The acceleration of biological aging is a risk factor for Alzheimer's disease (AD). Here, we performed weighted gene co‐expression network analysis (WGCNA) to identify modules and dysregulated genesinvolved in biological aging in AD.

Document Details

Document Type
Pub Defense Publication
Publication Date
Jan 01, 2022
Source ID
10.1002/dad2.12354

Entities

People

  • Andrew J. Saykin
  • Aparna Vasanthakumar
  • Bo‐hyun Kim
  • For The Alzheimer’s Disease Neuroimaging Initiative (adni)
  • Jeffrey F. Waring
  • Jong‐min Lee
  • Justin W. Davis
  • Kelly N.h. Nudelman
  • Kenneth Idler
  • Kwangsik Nho
  • Qingqin S Li
  • Sang Won Seo
  • Shannon L. Risacher

Organizations

  • Department of Health and Social Care
  • Hanyang University
  • Indiana University
  • National Institute of Biomedical Imaging and Bioengineering
  • National Institute on Aging
  • National Institutes of Health
  • Sungkyunkwan University
  • United States Department of Defense

Tags

Fields of Study

  • Biology

Readers

  • Oncology (Cancer Research).
  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.