The Caenorhabditis elegans proteasome subunit RPN‐12 is required for hermaphrodite germline sex determination and oocyte quality
Abstract
The proteasome is a multi‐subunit complex and a major proteolytic machinery in cells. Most subunits are essential for proteasome function, and depletion of individual subunits normally results in lethality. RPN‐12/Rpn12/PSMD8 is a lid subunit of the 19S regulatory particle (RP) of the 26S proteasome. Studies in Caenorhabditis elegans demonstrated that RNAi depletion of RPN‐12 does not result in lethality. RPN‐12 has not been well studied in higher eukaryotes. In this study, we investigate the biological significance of RPN‐12 in C. elegans.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 17, 2020
- Source ID
- 10.1002/dvdy.235
Entities
People
- Anna Allen
- Jeandele Elliot
- Lourds M. Fernando
Organizations
- Howard University
- United States Department of Defense