Knockout of the gene encoding the extracellular matrix protein SNED1 results in early neonatal lethality and craniofacial malformations
Abstract
The extracellular matrix (ECM) is a fundamental component of multicellular organisms that orchestrates developmental processes and controls cell and tissue organization. We previously identified the novel ECM protein SNED1 as a promoter of breast cancer metastasis and showed that its level of expression negatively correlated with breast cancer patient survival. Here, we sought to identify the roles of SNED1 during murine development.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 22, 2020
- Source ID
- 10.1002/dvdy.258
Entities
People
- Alexandra Naba
- Anna Barqué
- Christina L. Nicholas
- Emanuel De La Fuente
- Kyleen Jan
- Richard O. Hynes
Organizations
- Howard Hughes Medical Institute
- Massachusetts Institute of Technology
- National Cancer Institute
- United States Department of Defense
- University of Illinois at Chicago