A companion to the preclinical common data elements on neurobehavioral comorbidities of epilepsy: a report of the TASK3 behavior working group of the ILAE/AES Joint Translational Task Force
Abstract
The provided companion has been developed by the Behavioral Working Group of the Joint Translational Task Force of the International League Against Epilepsy (ILAE) and the American Epilepsy Society (AES) with the purpose of assisting the implementation of Preclinical Common Data Elements (CDE) for studying and for reporting neurobehavioral comorbidities in rodent models of epilepsy. Case Report Forms (CRFs) are provided, which should be completed on a per animal/per test basis, whereas the CDEs are a compiled list of the elements that should be reported. This companion is not designed as a list of recommendations, or guidelines for how the tests should be run—rather, it describes the different types of assessments, and highlights the importance of rigorous data collection and transparency in this regard. The tests are divided into 7 categories for examining behavioral dysfunction on the syndrome level: deficits in learning and memory; depression; anxiety; autism; attention deficit/hyperactivity disorder; psychosis; and aggression. Correspondence and integration of these categories into the National Institute of Mental Health (NIMH) Research Domain Criteria (RDoC) is introduced. Developmental aspects are addressed through the introduction of developmental milestones. Discussion includes complexities, limitations, and biases associated with neurobehavioral testing, especially when performed in animals with epilepsy, as well as the importance of rigorous data collection and of transparent reporting. This represents, to our knowledge, the first such resource dedicated to preclinical CDEs for behavioral testing of rodents.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 18, 2018
- Source ID
- 10.1002/epi4.12236
Entities
People
- Andréy Mazarati
- Aristea S Galanopoulou
- Astrid Nehlig
- Jana Veliskova
- Jesús‐servando Medel‐matus
- Karine Sarkisova
- Lauren C Harte-Hargrove
- Lisa E. Kalynchuk
- Liset Menendez De La Prida
- Nigel C. Jones
- Pierre‐pascal Lenck‐santini
Organizations
- Aix-Marseille University
- Albert Einstein College of Medicine
- Cajal Institute
- Institute of Higher Nervous Activity
- Monash University
- New York Medical College
- Paris Descartes University
- Russian Center for Science Information
- UCLA David Geffen School of Medicine
- University of California, Los Angeles
- University of Vermont
- University of Victoria