Molecular mechanisms of long noncoding RNAs‐mediated cancer metastasis
Abstract
Cancer metastasis is a multistep process that requires cancer cells to leave the primary site, survive in the blood stream, and finally colonize at a distant organ. It is the major cause of cancer morbidity and mortality. The organ‐specific colonization requires close interaction and communication between cancer cells and host organs. Noncoding RNAs represent the majority of the transcriptome, with long noncoding RNAs (lncRNAs) making up a significant proportion. It has been suggested that lncRNAs play a key role in all stages of tumorigenesis and metastasis. This review will provide an overview of how lncRNAs are involved in cancer cell colonization in specific organ sites and the underlying mechanisms as well as therapeutic strategies.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 08, 2019
- Source ID
- 10.1002/gcc.22691
Entities
People
- Chunru Lin
- Liuqing Yang
- Sergey D. Egranov
- Yajuan Li
Organizations
- Cancer Prevention and Research Institute of Texas
- Congressionally Directed Medical Research Programs
- National Cancer Institute
- National Institute of Diabetes and Digestive and Kidney Diseases
- University of Texas at Austin