Genetic, epigenetic, and post‐transcriptional basis of divergent tissue regenerative capacities among vertebrates
Abstract
Regeneration is widespread across the animal kingdom but varies vastly across phylogeny and even ontogeny. Adult mammalian regeneration in most organs and appendages is limited, while vertebrates such as zebrafish and salamanders are able to regenerate various organs and body parts. Here, we focus on the regeneration of appendages, spinal cord, and heart—organs and body parts that are highly regenerative among fish and amphibian species but limited in adult mammals. We then describe potential genetic, epigenetic, and post‐transcriptional similarities among these different forms of regeneration across vertebrates and discuss several theories for diminished regenerative capacity throughout evolution.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 17, 2021
- Source ID
- 10.1002/ggn2.10042
Entities
People
- Guo N Huang
- Sheamin Khyeam
- Sukjun Lee
Organizations
- Cardiovascular Institute Hospital
- National Heart, Lung, and Blood Institute
- United States Department of Defense