Affective symptoms and regional cerebral tau burden in early‐stage Alzheimer's disease
Abstract
Neuropsychiatric symptoms (NPS) are often present in individuals with mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia. NPS are associated with structural and functional changes in the brain such as atrophy, regional hypometabolism, and hypoperfusion, considered proxies of neurodegeneration. Our objective was to evaluate the association between NPS and regional cerebral tau burden, a more direct representation of neurodegeneration, in cognitively normal (CN), MCI, and AD dementia individuals.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 15, 2021
- Source ID
- 10.1002/gps.5530
Entities
People
- Christopher Gonzalez
- Danielle Briggs
- Gad A. Marshall
- Jennifer R. Gatchel
- Michael J. Properzi
- Nicole S Tommasi
- The Alzheimer’s Disease Neuroimaging Initiative*
Organizations
- Harvard Medical School
- National Institutes of Health
- United States Department of Defense