Compromised hippocampus‐striatum pathway as a potential imaging biomarker of mild‐traumatic brain injury and posttraumatic stress disorder
Abstract
Military service members risk acquiring posttraumatic stress disorder (PTSD) and mild‐traumatic brain injury (mTBI), with high comorbidity. Owing to overlapping symptomatology in chronic mTBI or postconcussion syndrome (PCS) and PTSD, it is difficult to assess the etiology of a patient's condition without objective measures. Using resting‐state functional MRI in a novel framework, we tested the hypothesis that their neural signatures are characterized by functionally hyperconnected brain regions which are less variable over time. Additionally, we predicted that such connectivities possessed the highest ability in predicting the diagnostic membership of a novel subject (top‐predictors) in addition to being statistically significant.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 15, 2017
- Source ID
- 10.1002/hbm.23551
Entities
People
- Adam M Goodman
- D Rangaprakash
- Gopikrishna Deshpande
- Jeffrey S. Katz
- Jennifer L Robinson
- Michael N Dretsch
- Nouha Salibi
- Thomas A. Daniel
- Thomas S. Denney Jr.
Organizations
- Auburn University
- Siemens Healthineers
- United States Army Aeromedical Research Lab
- United States Army Medical Research and Development Command
- University of Alabama
- University of California, Los Angeles
- Westfield State University