Functional hypergraph uncovers novel covariant structures over neurodevelopment
Abstract
Brain development during adolescence is marked by substantial changes in brain structure and function, leading to a stable network topology in adulthood. However, most prior work has examined the data through the lens of brain areas connected to one another in large‐scale functional networks. Here, we apply a recently developed hypergraph approach that treats network connections (edges) rather than brain regions as the unit of interest, allowing us to describe functional network topology from a fundamentally different perspective. Capitalizing on a sample of 780 youth imaged as part of the Philadelphia Neurodevelopmental Cohort, this hypergraph representation of resting‐state functional MRI data reveals three distinct classes of subnetworks (hyperedges): clusters, bridges, and stars, which respectively represent homogeneously connected, bipartite, and focal architectures. Cluster hyperedges show a strong resemblance to previously‐described functional modules of the brain including somatomotor, visual, default mode, and salience systems. In contrast, star hyperedges represent highly localized subnetworks centered on a small set of regions, and are distributed across the entire cortex. Finally, bridge hyperedges link clusters and stars in a core–periphery organization. Notably, developmental changes within hyperedges are ordered in a similar core–periphery fashion, with the greatest developmental effects occurring in networked hyperedges within the functional core. Taken together, these results reveal a novel decomposition of the network organization of human brain, and further provide a new perspective on the role of local structures that emerge across neurodevelopment. Hum Brain Mapp 38:3823–3835, 2017. © 2017 The Authors. Human Brain Mapping Published by Wiley Periodicals, Inc.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 11, 2017
- Source ID
- 10.1002/hbm.23631
Entities
People
- Danielle Bassett
- John D. Medaglia
- Muzhi Yang
- Raquel E. Gur
- Ruben C. Gur
- Shi Gu
- Theodore D Satterthwaite
Organizations
- Alfred P. Sloan Foundation
- Army Research Office
- Institute for Translational Medicine and Therapeutics
- John D. and Catherine T. MacArthur Foundation
- National Institute of Mental Health
- National Institutes of Health
- National Science Foundation
- Office of Naval Research
- United States Army Research Laboratory
- University of Pennsylvania