ENIGMA‐DTI: Translating reproducible white matter deficits into personalized vulnerability metrics in cross‐diagnostic psychiatric research
Abstract
The ENIGMA‐DTI (diffusion tensor imaging) workgroup supports analyses that examine the effects of psychiatric, neurological, and developmental disorders on the white matter pathways of the human brain, as well as the effects of normal variation and its genetic associations. The seven ENIGMA disorder‐oriented working groups used the ENIGMA‐DTI workflow to derive patterns of deficits using coherent and coordinated analyses that model the disease effects across cohorts worldwide. This yielded the largest studies detailing patterns of white matter deficits in schizophrenia spectrum disorder (SSD), bipolar disorder (BD), major depressive disorder (MDD), obsessive–compulsive disorder (OCD), posttraumatic stress disorder (PTSD), traumatic brain injury (TBI), and 22q11 deletion syndrome. These deficit patterns are informative of the underlying neurobiology and reproducible in independent cohorts. We reviewed these findings, demonstrated their reproducibility in independent cohorts, and compared the deficit patterns across illnesses. We discussed translating ENIGMA‐defined deficit patterns on the level of individual subjects using a metric called the regional vulnerability index (RVI), a correlation of an individual's brain metrics with the expected pattern for a disorder. We discussed the similarity in white matter deficit patterns among SSD, BD, MDD, and OCD and provided a rationale for using this index in cross‐diagnostic neuropsychiatric research. We also discussed the difference in deficit patterns between idiopathic schizophrenia and 22q11 deletion syndrome, which is used as a developmental and genetic model of schizophrenia. Together, these findings highlight the importance of collaborative large‐scale research to provide robust and reproducible effects that offer insights into individual vulnerability and cross‐diagnosis features.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 16, 2020
- Source ID
- 10.1002/hbm.24998
Entities
People
- Carrie E. Bearden
- Christopher R. K. Ching
- Dan J. Stein
- David C. Glahn
- David F Tate
- Dick J. Veltman
- Elisabeth A Wilde
- Emily L Dennis
- Fabrizio Piras
- Gary Donohoe
- Gianfranco Spalletta
- Jessica A. Turner
- Josselin Houenou
- Julio E. Villalon‐reina
- L. Elliot Hong
- Laura S. Van Velzen
- Laurena Holleran
- Lianne Schmaal
- Liz Haddad
- Mark W Logue
- Meghann C. Ryan
- Neda Jahanshad
- Odile A. Van Den Heuvel
- Ole A. Andreassen
- Paul M. Thompson
- Pauline Favre
- Peter Kochunov
- Rajendra A Morey
- Sinéad Kelly
- Talia M. Nir
- Theo G M van Erp
- Yunlong Tan
Organizations
- Assistance Publique – Hôpitaux de Paris
- Boston University
- Duke University
- European Research Council
- Georgia State University
- Hartford Hospital
- Harvard Medical School
- Health Research Board, Ireland
- National Health and Medical Research Council
- National Institute of Mental Health
- National Institutes of Health
- Oslo University Hospital
- Paris 12 University
- Peking University
- Research Council of Norway
- Science Foundation Ireland
- South African Medical Research Council
- United States Department of Defense
- University of California
- University of California, Los Angeles
- University of Cape Town
- University of Galway
- University of Maryland School of Medicine
- University of Melbourne
- University of Oslo
- University of Southern California
- University of Utah
- VA Boston Healthcare System
- Vrije Universiteit Amsterdam