Uncovering Biological Factors That Regulate Hepatocellular Carcinoma Growth Using Patient‐Derived Xenograft Assays
Abstract
Several major factors limit our understanding of hepatocellular carcinoma (HCC). First, human HCCs are infrequently biopsied for diagnosis and thus are not often biologically interrogated. Second, HCC initiation and progression are strongly influenced by the cirrhotic microenvironment, and the exact contributions of intrinsic and extrinsic tumor factors are unclear. A powerful approach to examine the personalized biology of liver cancers and the influence of host tissues is with patient‐derived xenograft (PDX) models. In Asia, HCCs from patients with hepatitis B virus have been efficiently converted into PDXs, but few parallel efforts from the west have been reported.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 01, 2020
- Source ID
- 10.1002/hep.31096
Entities
People
- Adam C. Yopp
- Akbar K Waljee
- Amit G. Singal
- Hao Zhu
- Hyesun Yoo
- Ji Zhu
- Lin Li
- Matthew R. Porembka
- Min Zhu
- Mobolaji Odewole
- Nicole E Rich
- Purva Gopal
- Sam C. Wang
- Sofia Kagan
- Tao Wang
- Tianshi Lu
- Veronica Renteria
Organizations
- Michigan Medicine
- University of Michigan
- University of Texas Southwestern Medical Center
- University of Texas at Austin